Chromosomal rearrangements involving the ends of chromosomes have emerged as an important cause of genetic disease given the gene-rich nature of the regions adjacent to the telomeres1. The importance of such subtelomeric chromosome rearrangements has been clearly shown by their observed association with unexplained mental retardation and congenital abnormalities2.
Individual subtelomere specific probes have been used to focus on particular subtelomeric regions, and have resulted in the establishment of syndromes such as the chromosome 1p36 deletion syndrome3,10and the 22q13.3 deletion syndrome4. The probes are also finding applications in the investigation of autistic disorders5, recurrent miscarriages6 and haematological malignancies7.
Cytocell’s subtelomere specific probes are located in the most distal region of chromosome specific DNA on each chromosome. Beyond this unique sequence material is the 100 to 300Kb region of telomere associated repeat followed by the cap of between 3 to 20Kb of tandemly repeated (TTAGGG)nsequence8.
The probes have been chosen from the most distal unique sequence to provide the best possible specificity, whilst also being applicable for routine use for the examination of subtelomeric enumeration and integrity.
The original second-generation set of probes is derived from PAC clones9 and was established in conjunction with the Institute of Molecular Medicine, part of Oxford University, in the UK11. Continuing product improvements have led to some substitutions with alternative cosmid (35-40Kb) or BAC (150Kb) clones to give improved signal strength or chromosome specificity. The average probe size is therefore 100Kb, and all have been mapped to within a maximum of 600Kb of the true telomere.
- Subtel FISH Probe 1p (Red)
- Subtel FISH Probe 1q (Red)
- Subtel FISH Probe 2p (Red)
- Subtel FISH Probe 2q (Red)
- Subtel FISH Probe 2qNP* (Red)
- Subtel FISH Probe 3p (Red)
- Subtel FISH Probe 3q (Red)
- Subtel FISH Probe 4p (Red)
- Subtel FISH Probe 4q (Red)
- Subtel FISH Probe 5p (Red)
- Subtel FISH Probe 5q (Red)
- Subtel FISH Probe 6p (Red)
- Subtel FISH Probe 6q (Red)
- Subtel FISH Probe 7p (Red)
- Subtel FISH Probe 7q (Red)
- Subtel FISH Probe 8p (Red)
- Subtel FISH Probe 8q (Red)
- Subtel FISH Probe 9p (Red)
- Subtel FISH Probe 9q (Red)
- Subtel FISH Probe 10p (Red)
- Subtel FISH Probe 10q (Red)
- Subtel FISH Probe 11p (Red)
- Subtel FISH Probe 11q (Red)
- Subtel FISH Probe 12p (Red)
- Subtel FISH Probe 12q (Red)
- Subtel FISH Probe 13q (Red)
- Subtel FISH Probe 14q (Red)
- Subtel FISH Probe 15q (Red)
- Subtel FISH Probe 16p (Red)
- Subtel FISH Probe 16q (Red)
- Subtel FISH Probe 17p (Red)
- Subtel FISH Probe 17q (Red)
- Subtel FISH Probe 18p (Red)
- Subtel FISH Probe 18q (Red)
- Subtel FISH Probe 19p (Red)
- Subtel FISH Probe 19q (Red)
- Subtel FISH Probe 20p (Red)
- Subtel FISH Probe 20q (Red)
- Subtel FISH Probe 21q (Red)
- Subtel FISH Probe 22q (Red)
- Subtel FISH Probe XYp (Red)
- Subtel FISH Probe XYq (Red)
- Subtel FISH Probe 1p (Green)
- SubtelFISH Probe 1q (Green)
- Subtel FISH Probe 2p (Green)
- Subtel FISH Probe 2q (Green)
- Subtel FISH Probe 2qNP* (Green)
- Subtel FISH Probe 3p (Green)
- Subtel FISH Probe 3q (Green)
- Subtel FISH Probe 4p (Green)
- Subtel FISH Probe 4q (Green)
- Subtel FISH Probe 5p (Green)
- Subtel FISH Probe 5q (Green)
- Subtel FISH Probe 6p (Green)
- Subtel FISH Probe 6q (Green)
- Subtel FISH Probe 7p (Green)
- Subtel FISH Probe 7q (Green)
- Subtel FISH Probe 8p (Green)
- Subtel FISH Probe 8q (Green)
- Subtel FISH Probe 9p (Green)
- Subtel FISH Probe 9q (Green)
- Subtel FISH Probe 10p (Green)
- Subtel FISH Probe 10q (Green)
- Subtel FISH Probe 11p (Green)
- Subtel FISH Probe 11q (Green)
- Subtel FISH Probe 12p (Green)
- Subtel FISH Probe 12q (Green)
- Subtel FISH Probe 13q (Green)
- Subtel FISH Probe 14q (Green)
- Subtel FISH Probe 15q (Green)
- Subtel FISH Probe 16p (Green)
- Subtel FISH Probe 16q (Green)
- Subtel FISH Probe 17p (Green)
- Subtel FISH Probe 17q (Green)
- Subtel FISH Probe 18p (Green)
- Subtel FISH Probe 18q (Green)
- Subtel FISH Probe 19p (Green)
- Subtel FISH Probe 19q (Green)
- Subtel FISH Probe 20p (Green)
- Subtel FISH Probe 20q (Green)
- Subtel FISH Probe 21q (Green)
- Subtel FISH Probe 22q (Green)
- Subtel FISH Probe XYp (Green)
- Subtel FISH Probe XYq (Green)