As long ago as the 19th Century, nuclear changes were recognised as being significant in cancer biology. Advances in cytogenetics and molecular cytogenetics in the last century showed that although a number of numerical and structural chromosome changes appeared to be random and non-specific, rearrangements involving individual chromosomes were shown to define specific abnormalities in individual tumour types.

Fluorescence In Situ Hybridisation (FISH) using locus-specific probes which are capable of defining these stereotypic structural rearrangements has now become a routine diagnostic test in the clinical laboratory. The technique has thus been shown to be useful in the management of cancer patients.
Cytocell offers a range of FISH probes specific for a number of haematological malignancies which are available in the Aquarius® liquid format. These probes are directly labelled, ready to use in hybridisation buffer and available in economical 5, and larger 10 test kits. The protocol is rapid and simple and has been developed to allow co-denaturation of the FISH probe and target DNA simultaneously.

The probe mixtures are designed for Fluorescence In Situ Hybridisation of interphase cells and metaphase chromosomes from cultured peripheral blood cells or cultured bone marrow samples.


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